A narrow bump occurs in D^*π^Three or moreD_One due to a D_1 resonance. A single resonance is found in J^P RNAi-mediated silencing =2^+ coupled to Dπ and D^*π. A relatively low mass and large coupling are found for the lightest D_1, suggestive of a state that will evolve into a broad resonance as the light-quark mass is reduced. An earlier calculation of the scalar D_0^* using the same light-quark mass enables comparisons to the heavy-quark limit.A weighted, semidiscrete, fast optimal transport (OT) algorithm for reconstructing the Lagrangian positions of protohalos from their evolved Eulerian positions is presented. The algorithm makes use of a mass estimate of the biased tracers and of the distribution of the remaining mass (the “dust”) but is robust to errors in the mass estimates. Tests with state-of-art cosmological simulations show that if the dust is assumed to have a uniform spatial distribution, then the shape of the OT-reconstructed pair correlation function of the tracers is very close to linear theory, enabling subpercent precision in the baryon acoustic oscillation distance scale that depends weakly, if at all, on a cosmological model. With a more sophisticated model for the dust, OT returns an estimate of the displacement field which yields superb reconstruction of the protohalo positions and, hence, of the shape and amplitude of the initial pair correlation function of the tracers. This enables direct and independent determinations of the bias factor b and the smearing scale Σ, potentially providing new methods for breaking the degeneracy between b and σ_8.We present an improved measurement of the carbon-nitrogen-oxygen (CNO) solar neutrino interaction rate at Earth obtained with the complete Borexino Phase-III dataset. The measured rate, R_CNO=6.7_-0.8^+2.0 counts/(day×100 tonnes), allows us to exclude the absence of the CNO signal with about 7σ C.L. The correspondent CNO neutrino flux is 6.6_-0.9^+2.0 Tolebrutinib ×10^8 cm^-2 s^-1, taking into account the neutrino flavor conversion. We use the new CNO measurement to evaluate the C and N abundances in the Sun with respect to the H abundance for the first time with solar neutrinos. Our result of N_CN=(5.78_-1.00^+1.86)×10^-4 displays a ∼2σ tension with the “low-metallicity” spectroscopic photospheric measurements. Furthermore, our result used together with the ^7Be and ^8B solar neutrino fluxes, also measured by Borexino, permits us to disfavor at 3.1σ C.L. the “low-metallicity” standard solar model B16-AGSS09met as an alternative to the “high-metallicity” standard solar model B16-GS98.Our objective was to assess factors associated with health-related quality of life (HRQoL) among men who have sex with men (MSM) living with or those not living with HIV in Nigeria. A cross-sectional subset of adult MSM in the ongoing TRUST/RV368 HIV prevention and treatment study were recruited and completed the World Health Organization quality of life in HIV infection (WHOQOL-BREF) questionnaire. The tool comprises physical health, psychological health, social relationships and environmental health domains from which scores were extracted. T-tests were used to compare mean HRQoL scores between participants living with or those not living with HIV and among persons living with HIV who had been on antiretroviral therapy for ≥1 year or less then 1 year. Of 322 study participants, 186 (57.8%) were living with HIV. The mean scores were significantly lower for participants living with HIV as compared to those not living with HIV in physical health, psychological health and social relationship domains. Among persons living with HIV and taking ART, scores were significantly lower for those whose duration was less then 1 year as compared to ≥1 year regarding physical health and psychological health. Strategies to improve HIV prevention and early detection and linkage to HIV care may improve HRQoL.Studies on HIV self-testing (HIV-ST) have been limited to adults (age 18+). The study assessed use of HIV-ST among a diverse group of young men who have sex with men (YMSM) in the United States (US) and assessed differences in uptake by demographic characteristics and requirements for parental consent. This study demonstrated feasibility of HIV-ST for YMSM as young as 14 years of age, which suggests potential for increasing HIV testing in this young age group and promoting health equity.With the rapid increase of diabetes cases in the world, there is an increasing demand for slowing down and managing diabetes and its effects. It is considered that a viable prophylactic treatment for type 2 diabetes mellitus (T2DM) is to reduce carbohydrate digestibility by controlling the activities of α-amylase and α-glucosidase to control postprandial hyperglycemia and promote the growth of intestinal beneficial bacteria. In this work, the effects of sulfonated lignin with different sulfonation degrees (0.8 mmol/g, SL1; 2.9 mmol/g, SL2) on the inhibition of α-amylase and α-glucosidase and the proliferation of intestinal beneficial bacteria in vitro were investigated. The results showed that both SL1 and SL2 can inhibit the activity of α-amylase and α-glucosidase. The inhibition capacity (IC50, 32.35 μg/mL) of SL2 with a low concentration (0-0.5 mg/mL) to α-amylase was close to that of acarbose to α-amylase (IC50, 27.33 μg/mL). Compared with the control groups, the bacterial cell concentrations of Bifidobacteria adolescentis and Lactobacillus acidophilus cultured with SL1 and SL2 increased in varying degrees (8-36%), and the produced short-chain fatty acids were about 1.2 times higher. This work demonstrates the prospect of sulfonated lignin as a prebiotic for the prevention and treatment of T2DM, which provides new insights for opening up a brand new field of lignin.It is widely recognized that psychological stress impairs performance for elite athletes, yet direct evidence is scarce when it comes to high-stakes competition because measuring real-time psychological stress without interference is often challenging. Contactless real-time heart rate-a technology-enabled biomarker of stress-was measured and broadcast on TV during the 2020 Tokyo Olympics archery competition for the first time in sports. Here we examined whether the real-time heart rate of 122 adult archers predicted their performance in this unique setting. We found that higher heart rate-which indicates an increase in psychological stress-is associated with lower scores, correlation coefficient r(2096) = -.076, p less then .001, and the observation is robust after we controlled for fixed effects at the individual and match level. Our results provide the first direct evidence in support of the detrimental effect of psychological stress measured by a real-time biomarker in a high-stakes competitive setting.This corrects the article DOI 10.1103/PhysRevLett.128.167001.The process of thermalization in many-body systems is driven by complex interactions among subsystems and a surrounding environment. Here we lay the theoretical foundations for the active control of local thermal states in arbitrary nonreciprocal systems close to their equilibrium state. In particular we describe how to (i) force some part of the system to evolve according to a prescribed law during the relaxation process (i.e., thermal targeting probem), (ii) insulate some elements from the rest of the system, or (iii) synchronize their evolution during the relaxation process. We also derive the general conditions a system must fulfill in order that some parts relax toward a minimal temperature with a minimum energetic cost or relax toward a prescribed temperature with a minimum time. Finally, we consider several representative examples in the context of systems exchanging heat radiatively.The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein-membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation.Bound state in a continuum (BIC) is a spatially confined resonance with its energy embedded in a continuous spectrum of propagative modes, yet their coupling is prohibited. In this Letter, we report the discovery of a generic non-Hermitian phenomenon that we call an “extended state in a localized continuum” (ELC). As the name suggests, the ELC is the inversion of the BIC-a single extended state embedded in a continuous spectrum entirely consisting of localized modes, and its emergence rests in the interplay between the BIC and the non-Hermitian skin effect (NHSE). Herein, the BIC is a zero-energy corner mode that spectrally overlaps with a bulk band in a Hermitian kagome lattice. The ELC emerges with the introduction of the NHSE in a particular way, such that it turns all the bulk states into corner skin modes and simultaneously delocalizes the corner mode. We experimentally realize the ELC using an active mechanical lattice. Our findings not only demonstrate the rich potential of the NHSE but may also spark new wave-based applications.We develop a first-principles model for the relativistic magnetic reconnection rate in strongly magnetized pair plasmas. By considering the energy budget and required current density near the x-line, we analytically show that in the magnetically dominated relativistic regime, the x-line thermal pressure is significantly lower than the upstream magnetic pressure due to the extreme energy needed to sustain the current density, consistent with kinetic simulations. This causes the upstream magnetic field lines to collapse in, producing the open outflow geometry which enables fast reconnection. The result is important for understanding a wide range of extreme astrophysical environments, where fast reconnection has been evoked to explain observations such as transient flares and nonthermal particle signatures.In the quantization of gauge theories and quantum gravity, it is crucial to treat reference frames such as rods or clocks not as idealized external classical relata, but as internal quantum subsystems. In the Page-Wootters formalism, for example, evolution of a quantum system S is described by a stationary joint state of S and a quantum clock, where time dependence of S arises from conditioning on the value of the clock. Here, we consider (possibly imperfect) internal quantum reference frames R for arbitrary compact symmetry groups, and show that there is an exact quantitative correspondence between the amount of entanglement in the invariant state on RS and the amount of asymmetry in the corresponding conditional state on S. Surprisingly, this duality holds exactly regardless of the choice of coherent state system used to condition on the reference frame. Averaging asymmetry over all conditional states, we obtain a simple representation-theoretic expression that admits the study of the quality of imperfect quantum reference frames, quantum speed limits for imperfect clocks, and typicality of asymmetry in a unified way. Our results shed light on the role of entanglement for establishing asymmetry in a fully symmetric quantum world.The kilometer square array (KM2A) of the large high altitude air shower observatory (LHAASO) aims at surveying the northern γ-ray sky at energies above 10 TeV with unprecedented sensitivity. γ-ray observations have long been one of the most powerful tools for dark matter searches, as, e.g., high-energy γ rays could be produced by the decays of heavy dark matter particles. In this Letter, we present the first dark matter analysis with LHAASO-KM2A, using the first 340 days of data from 1/2-KM2A and 230 days of data from 3/4-KM2A. Several regions of interest are used to search for a signal and account for the residual cosmic-ray background after γ/hadron separation. We find no excess of dark matter signals, and thus place some of the strongest γ-ray constraints on the lifetime of heavy dark matter particles with mass between 10^5 and 10^9 GeV. Our results with LHAASO are robust, and have important implications for dark matter interpretations of the diffuse astrophysical high-energy neutrino emission.Rotating or charged classical black holes in isolation possess a special surface in their interior, the Cauchy horizon, beyond which the evolution of spacetime (based on the equations of General Relativity) ceases to be deterministic. In this Letter, we study the effect of a quantum massless scalar field on the Cauchy horizon inside a rotating (Kerr) black hole that is evaporating via the emission of Hawking radiation (corresponding to the field being in the Unruh state). We calculate the flux components (in Eddington coordinates) of the renormalized stress-energy tensor of the field on the Cauchy horizon, as functions of the black hole spin and of the polar angle. We find that these flux components are generically nonvanishing. Furthermore, we find that the flux components change sign as these parameters vary. The signs of the fluxes are important, as they provide an indication of whether the Cauchy horizon expands or crushes (when backreaction is taken into account). Regardless of these signs, our results imply that the flux components generically diverge on the Cauchy horizon when expressed in coordinates which are regular there. This is the first time that irregularity of the Cauchy horizon under a semiclassical effect is conclusively shown for (four-dimensional) spinning black holes.Many phenomena and fundamental predictions, ranging from Hawking radiation to the early evolution of the Universe rely on the interplay between quantum mechanics and gravity or more generally, quantum mechanics in curved spacetimes. However, our understanding is hindered by the lack of experiments that actually allow us to probe quantum mechanics in curved spacetime in a repeatable and accessible way. Here we propose an experimental scheme for a photon that is prepared in a path superposition state across two rotating Sagnac interferometers that have different diameters and thus represent a superposition of two different spacetimes. We predict the generation of genuine entanglement even at low rotation frequencies and show how these effects could be observed even due to the Earth’s rotation. These predictions provide an accessible platform in which to study the role of the underlying spacetime in the generation of entanglement.We present a model of a strongly correlated system with a non-Fermi liquid high temperature phase. Its ground state undergoes an insulator to superconductor quantum phase transition (QPT) as a function of a pairing interaction strength. Both the insulator and the superconductor are originating from the same interaction mechanism. The resistivity in the insulating phase exhibits the activation behavior with the activation energy, which goes to zero at the QPT. This leads to a wide quantum critical regime with an algebraic temperature dependence of the resistivity. Upon raising the temperature in the superconducting phase, the model exhibits a finite temperature phase transition to a Bose metal phase, which separates the superconductor from the non-Fermi liquid metal.A Josephson diode is a nonreciprocal circuit element that supports a larger dissipationless supercurrent in one direction than in the other. In this Letter, we propose a class of Josephson diodes based on supercurrent interferometers composed of Andreev bound state Josephson junctions or interacting quantum dot Josephson junctions, which are not diodes themselves but possess nonsinusoidal current-phase relations. We show that such Josephson diodes have several important advantages, like being electrically tunable and requiring only time-reversal breaking by a magnetic flux. We also show that our diodes have a characteristic ac response, revealed by the Shapiro steps. Even the simplest realization of our Josephson diode paradigm that relies on only two junctions can achieve efficiencies of up to ∼40% and, interestingly, far greater efficiencies are achievable by concatenating interferometer loops. We hope that our Letter will stimulate the search for highly tunable Josephson diode effects in Josephson devices based semiconductor-superconductor hybrids, 2d materials, and topological insulators, where nonsinusoidal current-phase relations were recently observed.It is now widely accepted that quenches through the critical region of quantum phase transitions result in post-transition states populated with topological defects-analogs of the classical topological defects. However, consequences of the very nonclassical fact that the state after a quench is a superposition of distinct, broken-symmetry vacua with different numbers and locations of defects have remained largely unexplored. We identify coherent quantum oscillations induced by such superpositions in observables complementary to the one involved in symmetry breaking. These oscillations satisfy Kibble-Zurek dynamical scaling laws with the quench rate, with an instantaneous oscillation frequency set primarily by the gap of the system. In addition to the obvious fundamental significance of a superposition of different broken symmetry states, quantum coherent oscillations can be used to verify unitarity and test for imperfections of the experimental implementations of quantum simulators.We propose using trapped electrons as high-Q resonators for detecting meV dark photon dark matter. When the rest energy of the dark photon matches the energy splitting of the two lowest cyclotron levels, the first excited state of the electron cyclotron will be resonantly excited. A proof-of-principle measurement, carried out with one electron, demonstrates that the method is background free over a 7.4 day search. It sets a limit on dark photon dark matter at 148 GHz (0.6 meV) that is around 75 times better than previous constraints. Dark photon dark matter in the 0.1-1 meV mass range (20-200 GHz) could likely be detected at a similar sensitivity in an apparatus designed for dark photon detection.The modular commutator is a recently discovered entanglement quantity that quantifies the chirality of the underlying many-body quantum state. In this Letter, we derive a universal expression for the modular commutator in conformal field theories in 1+1 dimensions and discuss its salient features. We show that the modular commutator depends only on the chiral central charge and the conformal cross ratio. We test this formula for a gapped (2+1)-dimensional system with a chiral edge, i.e., the quantum Hall state, and observe excellent agreement with numerical simulations. Furthermore, we propose a geometric dual for the modular commutator in certain preferred states of the AdS/CFT correspondence. For these states, we argue that the modular commutator can be obtained from a set of crossing angles between intersecting Ryu-Takayanagi surfaces.We analyze the complexity of classically simulating continuous-time dynamics of locally interacting quantum spin systems with a constant rate of entanglement breaking noise. We prove that a polynomial time classical algorithm can be used to sample from the state of the spins when the rate of noise is higher than a threshold determined by the strength of the local interactions. Furthermore, by encoding a 1D fault tolerant quantum computation into the dynamics of spin systems arranged on two or higher dimensional grids, we show that for several noise channels, the problem of weakly simulating the output state of both purely Hamiltonian and purely dissipative dynamics is expected to be hard in the low-noise regime.Inducing transport in electrolyte-filled nanopores with dc fields has led to influential applications ranging from nanosensors to DNA sequencing. Here we use the Poisson-Nernst-Planck and Navier-Stokes equations to show that unbiased ac fields can induce comparable directional flows in gated conical nanopores. This flow exclusively occurs at intermediate driving frequencies and hinges on the resonance of two competing timescales, representing space charge development at the ends and in the interior of the pore. We summarize the physics of resonant nanopumping in an analytical model that reproduces the results of numerical simulations. Our findings provide a generic route toward real-time controllable flow patterns, which might find applications in controlling the translocation of small molecules or nanocolloids.We consider a chain of interacting fermions with random disorder that was intensively studied in the context of many-body localization. We show that only a small fraction of the two-body interaction represents a true local perturbation to the Anderson insulator. While this true perturbation is nonzero at any finite disorder strength W, it decreases with increasing W. This establishes a view that the strongly disordered system should be viewed as a weakly perturbed integrable model, i.e., a weakly perturbed Anderson insulator. As a consequence, the latter can hardly be distinguished from a strictly integrable system in finite-size calculations at large W. We then introduce a rescaled model in which the true perturbation is of the same order of magnitude as the other terms of the Hamiltonian, and show that the system remains ergodic at arbitrary large disorder.We study numerically the Toner-Tu field theory where the density field is maintained constant, a limit case of “Malthusian” flocks for which the asymptotic scaling of correlation functions in the ordered phase is known exactly. While we confirm these scaling laws, we also show that such constant-density flocks are metastable to the nucleation of a specific defect configuration, and are replaced by a globally disordered phase consisting of asters surrounded by shock lines that constantly evolves and remodels itself. We demonstrate that the main source of disorder lies along shock lines, rendering this active foam fundamentally different from the corresponding equilibrium system. We thus show that in the context of active matter also, a result obtained at all orders of perturbation theory can be superseded by nonperturbative effects, calling for a different approach.Nodal links are special configurations of band degeneracies in the momentum space, where nodal line branches encircle each other. In PT symmetric systems, nodal lines can be topologically characterized using the eigenvector frame rotations along an encircling loop and the linking structure can be described with non-Abelian frame charges involving adjacent bands. While the commutation rules between the frame charges are well established, the underlying relationship between distant band gap closing nodes remains to be explored. In this Letter, we present a photonic multiple nodal links system, where the nodal lines of nonadjacent bands are investigated with symmetry constraints on frame charges. Through an orthogonal nodal chain, the nodal line from the lower two bands predicts the existence of nodal lines formed between the higher bands. We designed and fabricated a metamaterial, with which the multiple nodal links and the topological connection between nonadjacent nodal lines are experimentally demonstrated.We advise a singular way of measuring topsy-turvy dispersing amplitudes. It requires the sort of a new log-normal syndication perform for that rates r_n=δ_n/δ_n+1 regarding (sequential) spacings δ_n among two (straight) peaks of the structural bioinformatics scattering plenitude.
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